publications

Health AI research spanning patient-centered health communication, clinical decision support, and trustworthy medical AI.

Our work spans Health AI across the care pathway—from accessible and personalized health information for patients to guideline-aligned reasoning, clinical decision support, and trustworthy AI for clinicians and researchers. See Google Scholar for citation counts and additional records.

2026

  1. EMNLP
    Does Accuracy Equal Evidence? Reasoning Faithfulness under KV Cache Compression
    Mengting Ai, Jingrui He, and Yue Guo
    In Findings of the Association for Computational Linguistics: EMNLP 2026, 2026
    PDF Code
  2. Trimming the Long-Tail of Visual World Modeling Evaluation
    Bingxuan Li, Yining Hong, Cheng Qian, Hyeonjeong Ha, Jiateng Liu, Zhenhailong Wang, Yue Guo, Yunzhu Li, and Heng Ji
    arXiv preprint arXiv:2606.24256, 2026
    PDF
  3. MolE-RAG: Molecular Structure-Enhanced Retrieval-Augmented Generation for Chemistry
    Joey Chan, Wonbin Kweon, Ashley Shin, Niharika Bhattacharjee, Pengcheng Jiang, Yue Guo, and Jiawei Han
    arXiv preprint arXiv:2606.05693, 2026
    PDF Code
  4. arXiv
    MedGuideX: Internalizing Decision Logic from Executable Guidelines into Large Language Models for Clinical Reasoning
    Yuhao Shen, Lang Cao, Simo Du, Yuqing Wang, Juexiao Zhou, Hao Peng, and Yue Guo
    arXiv preprint arXiv:2605.26567, 2026
    PDF
  5. COLM
    ReLay: Personalized LLM-Generated Plain-Language Summaries for Better Understanding, but at What Cost?
    Joey Chan, Yikun Han, Jingyuan Chen, Samuel Fang, Lauren D. Gryboski, Alexandra Lee, Sheel Tanna, Qingqing Zhu, Zhiyong Lu, Lucy Lu Wang, and Yue Guo
    In Conference on Language Modeling (COLM), 2026
    PDF
  6. COLM
    MedConceal: A Benchmark for Clinical Hidden-Concern Reasoning Under Partial Observability
    Yikun Han, Joey Chan, Jingyuan Chen, Mengting Ai, Simo Du, and Yue Guo
    In Conference on Language Modeling (COLM), 2026
    PDF
  7. COLM
    Joint Optimization of Reasoning and Dual-Memory for Self-Learning Diagnostic Agent
    Bingxuan Li, Simo Du, and Yue Guo
    In Conference on Language Modeling (COLM), 2026
    PDF
  8. Improving Clinical Diagnosis with Counterfactual Multi-Agent Reasoning
    Zhiwen You, Xi Chen, Aniket Vashishtha, Simo Du, Gabriel Erion-Barner, Hongyuan Mei, Hao Peng, and Yue Guo
    arXiv preprint arXiv:2603.27820, 2026
    PDF Code
  9. EHR-RAG: Bridging Long-Horizon Structured Electronic Health Records and Large Language Models via Enhanced Retrieval-Augmented Generation
    Lang Cao, Qingyu Chen, and Yue Guo
    arXiv preprint arXiv:2601.21340, 2026
    PDF
  10. EMNLP
    LONGQAEVAL: Designing Reliable Evaluations of Long-Form Clinical QA under Resource Constraints
    Federica Bologna, Tiffany Pan, Matthew Wilkens, Yue Guo, and Lucy Lu Wang
    In Findings of the Association for Computational Linguistics: EMNLP 2026, 2026
    PDF
  11. 2025-yue-llm.jpg
    Are LLM-generated plain language summaries truly understandable? A large-scale crowdsourced evaluation
    Yue Guo, Jae Ho Sohn, Gondy Leroy, and Trevor Cohen
    Journal of Biomedical Informatics, 2026
    PDF
  12. 2025-zhiwen-plainqafact.jpg
    PlainQAFact: Retrieval-augmented Factual Consistency Evaluation Metric for Biomedical Plain Language Summarization
    Zhiwen You, and Yue Guo
    Journal of Biomedical Informatics, 2026
    PDF Code

2025

  1. 2025-bohao-explainless.jpg
    Explain Less, Understand More: Jargon Detection via Personalized Parameter-Efficient Fine-tuning
    Bohao Wu, Qingyun Wang, and Yue Guo
    arXiv preprint arXiv:2505.16227, 2025
    PDF Code
  2. 2025-ming-knowledge.jpg
    Towards Knowledge-Guided Biomedical Lay Summarization using Large Language Models
    Shufan Ming, Yue Guo, and Halil Kilicoglu
    In CL4Health, 2025
    PDF
  3. 2025-cohen-coherence.jpg
    Coherence and comprehensibility: Large language models predict lay understanding of health-related content
    Trevor Cohen, Weizhe Xu, Yue Guo, Serguei Pakhomov, and Gondy Leroy
    Journal of Biomedical Informatics, 2025
    PDF

2024

  1. 2024-yue-personalization.jpg
    Personalized jargon identification for enhanced interdisciplinary communication
    Yue Guo, Joseph Chee Chang, Maria Antoniak, Erin Bransom, Trevor Cohen, Lucy Lu Wang, and Tal August
    In NAACL, 2024
    PDF Code
  2. 2024-appls.jpg
    APPLS: A meta-evaluation testbed for plain language summarization
    Yue Guo, Tal August, Gondy Leroy, Trevor Cohen, and Lucy Lu Wang
    EMNLP, 2024
    PDF Code
  3. 2024-yue-retrieval.jpg
    Retrieval augmentation of large language models for lay language generation
    Yue Guo, Wei Qiu, Gondy Leroy, Sheng Wang, and Trevor Cohen
    Journal of Biomedical Informatics, 2024
    PDF Code

2022

  1. Mixed-methods evaluation of three natural language processing modeling approaches for measuring documented goals-of-care discussions in the electronic health record
    Alison M Uyeda, J Randall Curtis, Ruth A Engelberg, Lyndia C Brumback, Yue Guo, James Sibley, William B Lober, Trevor Cohen, Janaki Torrence, Joanna Heywood, and  others
    Journal of Pain and Symptom Management, 2022

2021

  1. 2021-yue-automated.jpg
    Automated lay language summarization of biomedical scientific reviews
    Yue Guo, Wei Qiu, Yizhong Wang, and Trevor Cohen
    In Proceedings of the AAAI Conference on Artificial Intelligence, 2021
    PDF Code
  2. Crossing the “Cookie Theft” corpus chasm: applying what BERT learns from outside data to the ADReSS challenge dementia detection task
    Yue Guo, Changye Li, Carol Roan, Serguei Pakhomov, and Trevor Cohen
    Frontiers in Computer Science, 2021
    PDF

2020

  1. Spatial radiation dose influence on xerostomia recovery and its comparison to acute incidence in patients with head and neck cancer
    Yue Guo, Wei Jiang, Pranav Lakshminarayanan, Peijin Han, Zhi Cheng, Michael Bowers, Xuan Hui, Ilya Shpitser, Sauleh Siddiqui, Russell H Taylor, and  others
    Advances in radiation oncology, 2020
    PDF
  2. The performance of immunocytochemistry staining as triaging tests for high-risk HPV-positive women: a 24-month prospective study
    Yu-Cong Li, Yu-Qian Zhao, Ting-Yuan Li, Wen Chen, Guang-Dong Liao, Hai-Rui Wang, Hai-Ke Lei, Yue Guo, Qi Zhou, and  others
    Journal of Oncology, 2020
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2019

  1. Dose/volume histogram patterns in salivary gland subvolumes influence xerostomia injury and recovery
    Peijin Han, Pranav Lakshminarayanan, Wei Jiang, Ilya Shpitser, Xuan Hui, Sang Ho Lee, Zhi Cheng, Yue Guo, Russell H Taylor, Sauleh A Siddiqui, and  others
    Scientific reports, 2019
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  2. Voxel dose pattern for patient-reported dysphagia among head and neck cancer patients receiving definitive radiotherapy
    Z Cheng, K Sheikh, P Lakshminarayanan, W Jiang, P Han, Y Guo, E Cecil, L Sloan, AP Kiess, BR Page, and  others
    International Journal of Radiation Oncology, Biology, Physics, 2019
  3. Low peripheral blood leukocyte counts during radiation therapy for head and neck cancer predict distant relapse and dysphagia
    C Gui, Z Cheng, E Cecil, L Sloan, MP Deek, P Lakshminarayanan, Y Guo, P Han, TR McNutt, and H Quon
    International Journal of Radiation Oncology, Biology, Physics, 2019
  4. Evaluation of Patient vs. Provider Based Assessments of Xerostomia and Dysphagia Compared Against Weight Loss in the Irradiated Head and Neck Cancer Patient
    Y Guo, Z Cheng, E Cecil, P Lakshminarayanan, Y Lu, P Han, AP Kiess, TR McNutt, and H Quon
    International Journal of Radiation Oncology, Biology, Physics, 2019
  5. Definitive Management of Early Stage Oropharyngeal Carcinoma: A Comparison of Long Term Outcomes Following Transoral Surgery or Definitive Chemoradiation
    MP Deek, E Cecil, L Sloan, Z Cheng, P Han, K Sheikh, C Gui, Y Guo, P Lakshminarayanan, C Fakhry, and  others
    International Journal of Radiation Oncology, Biology, Physics, 2019
  6. A Feasibility Study of Xerostomia Outcome-Based Treatment Planning to Improve the Probability of Xerostomia Recovery in Head and Neck Cancer Patients
    Y Guo, P Lakshminarayanan, P Han, K Sheikh, Z Cheng, W Jiang, S Siddiqui, I Shpitser, R Taylor, H Quon, and  others
    International Journal of Radiation Oncology, Biology, Physics, 2019
  7. An Outcome-Based Treatment Planning Strategy to Improve Xerostomia Symptom in Head and Neck Cancer Patients
    Y Guo, P Lakshminarayanan, P Han, K Sheikh, Z Cheng, S Siddiqui, I Shpitser, R Taylor, H Quon, and T McNutt
    In MEDICAL PHYSICS, 2019

2018

  1. Quality of life differences in male and female patients with head and neck cancer
    BR Page, Y Guo, P Han, Z Cheng, J Harkness, C Shen, A Choflet, C Hu, E Cecil, NC Schmitt, and  others
    International Journal of Radiation Oncology, Biology, Physics, 2018
  2. Head and Neck Salivary Gland Spatial Dose-Volume histogram (DVH) Patterns Predict Radiation-Induced Xerostomia, From Injury to Recovery
    P Han, P Lakshminarayanan, W Liang, I Shpitser, X Hui, S Lee, Z Cheng, Y Guo, R Taylor, S Siddiqui, and  others
    In MEDICAL PHYSICS, 2018