Portrait of Yue Guo
Yue Guo

Assistant Professor

School of Information Sciences
University of Illinois Urbana-Champaign

614 E. Daniel Street · Room 4131 · Champaign, IL

I am an Assistant Professor in the School of Information Sciences at the University of Illinois Urbana-Champaign, affiliated with the Siebel School of Computing and Data Science, the Health Care Engineering Systems Center, the Carle Illinois College of Medicine, and the National Center for Supercomputing Applications. My research centers on Medical AI. I study how AI agents can learn from human expertise and reason across the longitudinal, multimodal evidence that shapes clinical decisions. My research goal is to design human-centered medical AI systems that move beyond possessing medical knowledge to meaningfully support how clinicians, patients, and researchers think, interact, and collaborate.

Research focus

Our work is organized around four questions: how agents learn clinical expertise; how to test them in realistic settings; how they reason across time and modalities; and how they affect human decisions and communication.

More about our research

Selected awards & honors

  • 2026ARCHES Faculty Fellowship, OSF HealthCare
  • 2026New Faculty Highlight, AAAI
  • 2025Arnold O. Beckman Research Award, UIUC
  • 2025Edward H. Shortliffe Doctoral Dissertation Award Finalist, AMIA

Prospective students: I plan to recruit PhD and master's students beginning in Fall 2027. Please see the Group page for research fit and application information.

News

Sep 27, 2026 Our new MedRouter preprint studies how a medical AI agent can identify and consult complementary specialist models rather than rely on a single model for every question. Across eight text and multimodal medical QA benchmarks, it improves average accuracy by 8% over the strongest routing baseline.
Aug 24, 2026 Two of our papers have been accepted to Findings of EMNLP 2026! Does Accuracy Equal Evidence? studies reasoning faithfulness under KV-cache compression, while LONGQAEVAL develops reliable, resource-conscious evaluation methods for long-form clinical QA. Congratulations to the students and collaborators who made this work possible! 🎉
Jul 28, 2026 GuideSkill turns clinical guidelines into an external library of executable diagnostic skills that can be inspected, updated, and reused across LLMs. Guideline-derived skills outperform guideline RAG, while case-driven evolution expands their diagnostic coverage.
Jul 20, 2026 A clean sweep at COLM 2026: 3/3 papers accepted! ReLay studies the benefits and risks of personalized health summaries; MedConceal tests how well models uncover and address patients’ hidden concerns; and SEA learns reusable diagnostic rules through jointly optimized reasoning and dual memory. I’ll be in San Francisco for the conference—please say hello! 🌉🎉
May 26, 2026 MedGuideX turns clinical practice guidelines into executable decision logic for LLM training, improving average clinical-reasoning accuracy by 10.28% and producing physician-preferred rationales. 🩺